GLP1.tools

GLP-1 Cost Calculator

Estimate your monthly and annual cost for semaglutide or tirzepatide based on your insurance coverage and savings program eligibility.

How GLP-1 Costs Are Determined

GLP-1 medication costs depend on three factors: which medication you take, your insurance coverage type, and whether you qualify for manufacturer savings programs.

Manufacturer Savings Cards

Both Novo Nordisk (for Wegovy/Ozempic) and Eli Lilly (for Zepbound/Mounjaro) offer savings cards that reduce monthly costs to as little as $25 for eligible commercially insured patients. These cards are free to apply for and are the single most impactful cost reduction available.

  • Wegovy / Ozempic: Apply at NovoCare.com
  • Zepbound / Mounjaro: Apply at Zepbound.com or Mounjaro.com

Savings cards require active commercial insurance. They are not available for Medicare or Medicaid patients.

Zepbound Self-Pay Vials

For uninsured patients, Eli Lilly introduced Zepbound single-dose vials in late 2024 — the same medication without the autoinjector pen. Available directly at LillyDirect.com:

  • 2.5 mg vials: ~$399/month
  • 5 mg vials: ~$499/month
  • 7.5–15 mg vials: ~$549/month

No equivalent self-pay option exists for semaglutide, making tirzepatide the clear choice for uninsured cash-pay patients.

Prior Authorization

Most insurance plans require prior authorization (PA) before covering obesity medications. Your provider submits documentation of your BMI and qualifying conditions. If denied, appeals succeed in a meaningful percentage of cases — especially with a letter of medical necessity from your provider.

How much does GLP-1 cost per month with insurance?
With commercial insurance and a manufacturer savings card, most patients pay $25–100/month. Without the savings card, $150–400. Medicare patients pay $100–300/month for Wegovy (cardiovascular indication).
What is the cheapest GLP-1 without insurance?
Zepbound self-pay vials at $399–549/month (LillyDirect.com) are the most affordable branded option. No equivalent exists for semaglutide.
Will insurance cover GLP-1 for weight loss?
Commercial plans vary widely — some cover Wegovy or Zepbound for obesity; others exclude weight loss medications. Prior authorization is typically required. Your provider submits documentation of BMI ≥30 (or ≥27 with comorbidity) to support coverage.